DNA reverse gyrase

RN = EC 5.99.1.-
SY = reverse gyrase
HM = *DNA Topoisomerases, Type I
II = DNA Topoisomerases, Type I, Bacterial
II = DNA Topoisomerases, Type I, Archaeal
PI = *DNA Topoisomerase (ATP-Hydrolysing) (1985-2001)
SO = Nature 1984;309(5970):669
FR = 43
NO = An atypical topoisomerase found in hyperthermophilic microorganisms, such as archaea and hyperthermophilic eubacteria. Reverse gyrase is able to positively supercoil DNA in the presence of ATP as helicases. In recent literature, it is classified as one of the Type I DNA topoisomerases (including topoisomerase I, III, V, and reverse gyrase). Previously, this enzyme was indexed under DNA Topoisomerase (ATP-Hydrolysing), a Type II DNA topoisomerase.
DA = 19840724
MR = 20010905
UI = C041813